The Anisotropy in the mechanical properties of the rocks is due to the presence of discontinuous plates in them. This paper examines the Anisotropy of the mechanical properties of sandstone. Due to the abundance of sandstone in Iran and the implementation of many projects in this type of rock, this issue was chosen. The mismatch in the mechanical properties of sandstone is due to the presence of layering surfaces. The Anisotropy in permeability, single-axis compressive strength, tensile strength, three-axis compressive strength, adhesion and internal friction angle have been investigated in this paper. Meanwhile, the unevenness of the rock decreases with increasing enclosure pressure.